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TOLERABILITY AND ADVERSE EVENTS The most common adverse events associated with GLP-1 receptor agonist use in general are gastrointestinal in nature, with mild-to-moderate diarrhea, nausea, and vomiting being the most commonly reported events
Because GLP-1 levels normalize, dopamine pathways rebound, microbiome damage persists, and SCFA-based satiety signals remain impaired
For example, the SUSTAIN trials evaluating semaglutide and the AWARD trials assessing dulaglutide did not identify yeast infections as a safety signal
Meanwhile, several additional GLP-1RAs were developed
Other anti-inflammatory peptides such as KPV work through distinct pathways and are frequently studied alongside this compound in inflammatory research designs
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