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It is mainly found in the cytosol of cells, while MAO is found in the mitochondria.[ref] Recent studies on aggression and mood have looked at the interaction between slow COMT activity and low MAOA activity

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Tatsuta Y, Kasai K, Maruyama C, et al

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Subsequent studies confirmed senolytic activity in additional cell types including chondrocytes, Leydig cells, keloid fibroblasts, and endothelial cells demonstrating that the FOXO4-p53 dependency is a conserved feature across multiple senescent cell populations

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