Cancer Cell , 2014, 26: 623637 Ruf B, Greten TF, Korangy F
These resolved spontaneously within 23 weeks without dose adjustment
References Jimnez-Reina, L., Caete, R., de la Torre, M
This strategy is assumed to act to reduce the selective pressure for resistance development since exposure has no consequence on bacterial survival

Primary Cellular Pathways GLP-1 Receptor Activation GLP1 Component GLP1 activates glucagon-like peptide-1 receptors expressed throughout the central nervous system and peripheral tissues, producing multiple metabolic effects: Insulin secretion enhancement in pancreatic beta cells in a glucose-dependent manner Glucagon suppression reducing hepatic glucose output and glycogenolysis Gastric emptying delay slowing nutrient absorption and prolonging satiety signals Central appetite suppression through hypothalamic GLP-1 receptor activation Beta cell preservation with potential enhancement of pancreatic beta cell function Research demonstrates that GLP1s 94% structural homology to native GLP-1, combined with modifications at positions 8, 26, and 34, provides resistance to dipeptidyl peptidase-4 degradation while maintaining full receptor activation

Combined organ transplant, donors or recipients with vascular anomalies, urgency transplants and re-transplantations were excluded from the study enrollment