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The answer to this is that we do not know for sure, Dr
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In some cases , people and their healthcare providers may decide to stay at 0.5 mg or 1.0 mg weekly instead of increasing further
The STEP (Semaglutide Treatment Effect in People with obesity) trials showed that semaglutide 2.4 mg weekly resulted in mean weight loss of 12-15% over 68 weeks compared to placebo
Clinicians should evaluate for contraindications specific to GLP-1 receptor agonists, including: Personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 History of pancreatitis or gallbladder disease Severe gastroparesis or gastrointestinal disease History of suicidal ideation or behavior Pregnancy or planned pregnancy (pregnancy testing when appropriate) Diabetic retinopathy (requires monitoring in patients with diabetes) Baseline investigations should include TSH, free T4, complete metabolic panel, lipid profile, and hemoglobin A1c (if diabetic or prediabetic)
Effects on blood pressure were not the primary outcome in the included trials and changes in background antihypertensive medication may have influenced the findings
