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Mechanism 2
Unlike GLP-1, GIP suppresses glucagon secretion under hyperglycemic conditions
Toxicon 59(4):464471 Garber AJ (2011) Long-acting glucagon-like peptide 1 receptor agonists: A review of their efficacy and tolerability
Its not recommended for long-term use (typically limited to 3-4 month cycles), may cause irritation and contact dermatitis, and poses a risk of ochronosis (blue-black discoloration) with prolonged use, particularly in deeper skin tones
Measured Growth-hormone release, alongside ACTH and cortisol - two stress-axis hormones that the earlier secretagogues tended to disturb
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