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Critically, research by Leal-Cerro and colleagues confirmed that endogenous GHRH is required for most of the GH response to GHRP-6, demonstrating that GHRPs work synergistically with the hypothalamic GHRH system rather than independently from it

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Similarly to how free radicals damage surface skin cells, keratinization of the skin, when the epithelial cells lose their moisture and become hard and dry, can occur in the mucous membranes of the respiratory, gastrointestinal tract and urinary tract