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Three situations require modification: Renal impairment (eGFR below 60 mL/min/1.73 m) Tirzepatide is not renally cleared (it's metabolized by proteolysis), so renal impairment doesn't directly affect drug levels

Diarrhea is more common with tirzepatide, while semaglutide users may experience constipation instead

It also slows down the rate that food moves out of the stomach and into the small intestine

Preclinical and observational evidence, as well as some small studies, suggested potential benefits of GLP-1 agonists, but this large trial does not confirm clinical efficacy in early Alzheimers. Have the authors taken confounding factors into account

Don't forget the lean protein: One of the ways a high-protein diet helps you lose weight is by triggering the release of your body's own natural GLP-1

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