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140 ERAD also modulates hepatic endocrine signaling by controlling the transcription of FGF21, a hormone that enhances energy expenditure and insulin sensitivity

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In db/db mice, administration of M-920, a caspase inhibitor, reduced renal CASP1, IL-1, IL-18, and NLRP3 inflammasome activation, leading to amelioration of albuminuria and renal ECM accumulation (198)

Hyperhomocysteinemia: An Independent Risk Factor for Thrombosis Recent studies underline the major role of moderate hyperhomocysteinemia on the odds of developing both arterial and venous thromboembolisms (Boers, 1997a