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Although the results for probing depth and gingival recession were not statistically significant, the single injection group demonstrated a significant therapeutic effect in improving bone defect depth (P = 0.0083)an outcome that is challenging to achieve with current non-surgical clinical treatments (Supplementary Table 11)
Some protocols describe injecting near the area of interest (for example, close to an injured tendon in animal research), based on the hypothesis of a localized effect
Label the can so you know it contains needles
They start with 510 shots over a few weeks, then gradually space them farther apart, sometimes by months
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