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Side effects make sense : Nausea, constipation, and bloating are direct consequences of slowed gastric emptying
In the large semaglutide and tirzepatide obesity trials led by Wilding (2021) and Jastreboff (2022), gastrointestinal symptoms were the most common side effects, were generally mild to moderate, clustered around the dose-escalation phase, and eased over time for most people
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Avoiding trigger foodsparticularly those high in fat, which further slow gastric emptyingmay decrease nausea and associated headaches
This elevation in GIP contributes to weight loss and improved glycemic control in SG patients [105]
Improved Glycemic Control Studies show Semaglutide may: Enhance insulin secretion Reduce glucagon release Improve fasting and postprandial glucose stability 3
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