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The histidine imidazole nitrogen, the glycine -amino group, and the glycine carbonyl oxygen coordinate to the Cu ion in a square-planar geometry, creating a stable chelate with a dissociation constant in the femtomolar range
doi: 10.1007/s00430-021-00727-0 167 LinY.XuY.ZhangZ
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The METAOD006 (OPTIONS) oral Phase 2b trial measured weight at 12 and 24 weeks
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