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Another preclinical study using presymptomatic and symptomatic SOD1 G93A transgenic mice revealed an association between the accumulation of ceramides and cholesterol esters in the spinal cords of ALS patients and OS, thus highlighting the pivotal role of OS in inducing an alteration in the metabolism of sphingolipids metabolism which mediates MN death in ALS [112]
Starting at this low dosejust 6.7% of the final maintenance doseis essential for the gradual adaptation process
Science 332 , 14291433 (2011)
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