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Metabolic effects: Enhanced lipolysis and protein synthesis via raised IGF-1 [8]
Side effect profiles also differ: semaglutide is more associated with nausea, while tirzepatide more commonly causes diarrhea
Activation of GIP receptors may further support fat metabolism and insulin sensitivity, whilst glucagon receptor agonism is believed to increase energy expenditure and promote the breakdown of stored fat (lipolysis)
Vitamin B12 deficiency can be sneaky and harmful
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