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Arch Dermatol 2009;145(2):157162
Beyond sleep, DSIP has demonstrated a remarkably broad research profile: it modulates the HPA stress axis by reducing basal cortisol and ACTH levels, enhances endogenous opioid signalling to raise pain thresholds without tolerance development, and upregulates antioxidant defence enzymes including SOD, catalase, and glutathione peroxidase
2) In single-dose studies of TCM formula extracts or crude drugs, the pharmacological effects are still controversial
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