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Types of alpha-lipoic acid supplements Outside of standard racemic ALA and purified R-ALA which weve covered above youll also find a few other supplement formats designed to enhance absorption, reduce side effects, or combine ingredients for synergistic effects: Encapsulated or time-release ALA These formulations gradually release ALA over several hours rather than all at once.62 Slower absorption may reduce gastrointestinal side effects like nausea or reflux and help maintain more stable blood levels throughout the day

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Am J Physiol Endocrinol Metab 303(1):E103E110 Hatoum IJ et al (2012) Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery