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Description

A FePt-based biomimetic nanocapsule FP/Vad@CC-aT2 modified with triggering receptor 2 (TREM2) expressed on myeloid cells for delivering the STING agonist Vadimezan (Vad), where anti-TREM2 can effectively repolarize TAMs into M1 macrophages thereby reversing the immunosuppressive TME together with the Vad-activated STING pathway and inhibiting tumor recurrence (69)

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