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Many proteins which underwent dysregulated abundance under both basal and ROS conditions were reductases, oxidases, stress response proteins and enzymes with oxidising products (Supplementary Tables S3 and S4)

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Molecular modelling and mutagenesis studies indicate that agonist positive allosteric modulators target the same general region, but in a distinct sub-pocket at the interface between helices V and VI, which may facilitate the formation of an intracellular binding site that enhances G-protein coupling