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Embedding of alkyl bromide warheads into non-covalent inhibitors enables covalent modification of a glutamate in the lipoprotein binding chaperone - phosphodiesterase of retinal rod subunit delta (PDE), which shuttles prenylated lipoproteins between cellular membranes and thereby mediates their activity
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A patent filed by Novo Nordisk A/S explained the hybrid method using rDNA technology and chemical synthesis for cost-efficient production of GLP-1 analogues
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How CW, Rasedee A, Manickam S, Rosli R
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