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Higashiyama, A., Htay, H

Is the acetate salt of a synthetic cyclic heptapeptide with the sequence cyclo-(Ac-Nle4-cyclo[Asp5-His6-D-Phe7-Arg8-Trp9-Lys10])-NH2, representing a conformationally constrained, metabolically stabilised derivative of the -MSH(4-10) pharmacophore core in which the Asp5 and Lys10 side chains are bridged by a lactam bond to form the cyclic backbone, Nle4 replaces methionine to prevent oxidative inactivation, and D-Phe7 replaces native phenylalanine to confer endopeptidase resistance and stabilise the receptor-binding pharmacophore conformation

Allergic Reactions (Rare) Though rare, some individuals may experience allergic reactions such as rashes, itching, or swelling, especially if they have sensitivities to certain ingredients in the supplement

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Imiquimod cream is applied directly to melanoma metastases to enhance an immune response to the tumour

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