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Effectiveness also depends on effective absorption of the medication, and the pill must be taken in a specific way to make sure it is absorbed properly. The Rybelsus pill reduced A1C slightly less than the Ozempic injection, by about 1.0 % to 1.3 % from baseline over 26 weeks

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Investigations into biased agonism, where medications are designed to selectively activate beneficial GLP-1 receptor pathways while minimizing those that cause side effects, could eventually produce GLP-1 medications with significantly reduced dry mouth profiles

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