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Publisher Journal of Cachexia, Sarcopenia and Muscle Accessed Jun 27, 2026 Study type Systematic Review Limitations: Lean mass is not identical to contractile muscle, and body-composition findings do not create a personal treatment plan
Grivennikov, S.I., Greten, F.R
In vivo , in the hippocampal tissues of mice exposed to PS-MPs, there was a significant increase in the mRNA expression levels of inflammation-related genes ( Tnf-a , Il-1b , Il-6 , Cxcl10 , and Mcp-1 ), indicating heightened inflammatory responses ( In vitro studies indicate PS has the capacity to bind to and activate BV2 microglial cells, thereby inducing pro-inflammatory reactions and activating inflammatory pathways, such as the NF-B pathway, which results in the production of pro-inflammatory cytokines ( in vitro and in vivo evidence converge to highlight oxidative stress and subsequent neuroinflammation as pivotal events in MPs-induced neurotoxicity
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