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However, retatrutide may have superior benefits for insulin resistance and glycemic regulation , due to: Enhanced insulin sensitivity from GIP agonism Reduced hepatic glucose output from glucagon signaling modulation Improved beta-cell function Clinical Insight: Retatrutide reduced fasting glucose and A1C levels with similar or better efficacy than tirzepatide in early trials

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The FDA states that when taking a drug for its approved use, you can be sure the agency has conducted a careful evaluation of its benefits and risks for that use, the decision to use the drug is supported by strong scientific data, and there is approved drug labeling for healthcare providers on how to use the drug safely and effectively for that use (FDA)

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Tissues were infiltrated with paraffin and H&E sections were obtained