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Cancer Cell 21 , 309322 (2012)
Low levels of GSH have been reported in cardiovascular disease, cancer, AIDS, autism, alcoholism, and debilitating neurodegenerative diseases such as Alzheimer's and Parkinson's
Moreover, several parameters such as body weight, blood glucose level and lipid profile are improved and other organs are not explored in this study
Within the set of tested PROTACs, a trend towards reduced effects on cell viability was observed for PROTACs carrying an amide group connecting the CCW16 ligand and the chemical linker moiety, which was introduced for synthetic reasons, compared to the derivatives and CCW16 lacking an amide bond at this position
The gut microbiota can influence the composition of lipids in the hosts serum, adipose tissue, and liver, particularly triglycerides and phosphatidylcholine, thereby impacting the hosts energy and lipid metabolism [54]
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