Constructing a fingerprint based on PCDimmunemetabolic combination biomarkers is a prerequisite for answering which type of patients are more likely to benefit from pyroptosis inhibition or ferroptosis inhibition. At the level of timing, the required direction of PCD regulation differs at different stages for the same patient: during the early phase of acute exacerbation (especially during infection and neutrophilic inflammatory storm), short-term inhibition of the NLRP3IL-1 axis, necrotic apoptosis, or ferroptosis may be considered to limit irreversible structural damage (302)
Antioxidants (2020)
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The decision point: continue bi-weekly into months 4 to 6 for full structural remodeling, or shift to monthly maintenance
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