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Answer: In a 48-week phase 2 trial, participants on the highest retatrutide doses lost up to roughly 24 percent of body weight, a figure that exceeded results reported for currently approved single and dual agonists

Among those who stayed on treatment for the full 68 weeks, cagrilintide 2.4 mg delivered an average of about 12% body weight reduction , compared to 2.3% for placebo

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Jiang X, Liu B, Nie Z, Duan L, Xiong Q, Jin Z, et al

GLP-1 receptors are expressed abundantly throughout the pancreas, and in response to GLP-1 therapy, the cells of the pancreas proliferate, swelling the organ, and potentially squeezing off ducts, causing inflammation, at least in rats

A clinical trial showed that tirzepatide was effective in achieving weight loss of 10-20% of total body weight for those using it along with lifestyle changes