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J Gerontol A Biol Sci Med Sci 2013

Randomization occurred after baseline assessments, with participants assigned in a 1:1:1:1 ratio to receive either a placebo or one of three BMT doses including 0.75, 1.25, or 1.75 mg

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Despite these benefits, these trials assessed cardiovascular clinical endpoints rather than myocardial structure or ECM collagen deposition, and thus do not establish a fibrosis-mediated mechanism