That mechanism was validated at meaningful scale: the pivotal trial program supporting FDA approval enrolled 816 HIV-infected adults with clinically defined lipodystrophy, one of the larger controlled datasets behind any peptide discussed in this category
When water enters the skin, it hydrates cells as well as the extracellular matrix, which can reduce the appearance of fine lines and wrinkles
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It def catches eyes when other tradesmen see it
Retinol (Vitamin A) and vitamin C promote collagen synthesis indirectly retinol via retinoic acid receptor signaling, vitamin C as a co-factor in collagen cross-linking
Controlled human trials exist, but they're limited in size, focused mostly on topical cosmetic use, and usually last only a few weeks or months. That means a lot of the exciting claims, especially around gene expression, systemic repair, and anti-aging effects, haven't been confirmed in large-scale human studies