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Pernicious anemia is associated with an increased incidence of carcinoma of the stomach, but this is believed to be related to the underlying pathology and not to treatment with cyanocobalamin

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May increase the risk of bleeding when used with blood-thinning drugs Case reports Shortness of breath, mild chest pain, and blood clot: Causing a patient to undergo a repeat valve replacement after self-substituting nattokinase for warfarin for a long period of time