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MC1R, present on melanocytes in the skin, controls melanogenesis, that is, the production of pigment

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Compared with GLP-1 receptor agonists, initiation of SGLT2 inhibitors was associated with a rate reduction of hospitalization for heart failure, with larger benefit among frailer people on an absolute rate scale, the researchers wrote

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This is done to manage potential side effects (like water retention) and to optimize cost

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