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Oxidative stress assessment by ferrous iron xylenol orange oxidation assay To evaluate hydrogen peroxide (H 2 O 2 ) production, we used the Ferrous Iron Xylenol Orange Oxidation (FOX) assay (PeroxiDetect Kit, Merck Sigma-Aldrich), following established protocols [27, 28]
78 Additionally, the disruption of the DLG motif-mediated interaction between Nrf2 and Keap1 stabilizes Nrf2 by preventing its ubiquitination, thereby amplifying the cellular antioxidant response and further suppressing ferroptosis
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7DF), indicating a dual mechanism of DMF on their regulation dependent on both NRF2 binding and DNA hydroxymethylation
Use of GLP-1 receptor agonists and subsequent risk of alcohol-related events
Hara et al
