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Chamoun K, Benton CB, AlRawi A, Jacamo R, Williams P, Wang F, Zhang J, Daver N, Kantarjian K, Konopleva M, Futreal A, Andreeff M

CTLA-4 functions by outcompeting the co-stimulatory receptor CD28 for binding to ligands CD80 and CD86 on antigen-presenting cells, leading to an inhibitory signal that dampens T-cell activation (64). Essentially, the glycolytic lactate in GBM promotes Treg cell function and tumor evasion of the bodys immune system

The combination treatment enhanced mitochondrial oxidative phosphorylation, reduced glycolysis, and increased reactive oxygen species production, leading to mitochondrial membrane depolarization, activation of apoptosis, and suppression of cell proliferation

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