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This dual effect on both positive and negative reinforcement mechanisms suggests that GLP-1RAs may reduce alcohol use through multiple neurobiological pathways

Chang W, Zhu F, Zheng H, Zhou Z, Miao P, Zhao L, Mao Z

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We observed a pronounced vehicle-corrected weight loss of 15.2% in the group treated with GLP-1MK-801 compared with 3.5% in the group treated with the parent GLP-1 analogue after 9 days of treatment, underscoring that the weight-lowering efficacy of the conjugate is intact in the absence of functional MC4R signalling (Fig

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