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About 98% of the carnitine in the human body is present in skeletal and heart muscle
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As in the LEAN study, the primary outcome is histologic resolution of NASH without worsening of fibrosis after 72 weeks of treatment, while secondary outcomes include improvement in liver fibrosis (1 stage) with no worsening of NASH, NAFLD activity score, as well as multiple serum markers of fibrosis
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Rigorous human clinical trials are lacking for this specific peptide in documenting safety and efficacy
The standard 4-week dose escalation used in clinical GH secretagogue trials exists because it allows researchers to identify the minimum effective dose before committing to longer protocols
