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This can lead to: Puffy hands or feet Morning stiffness in the joints Mild carpal tunnel-like sensations Reducing the dose or spacing out injections may help minimize these symptoms

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doi: 10.1016/S0140-6736(21)00213-0 137 Tall BullSNufferWTrujilloJM

Less commonly used today, but still helpful in selected patients with insulin resistance and fatty liver