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Arch Biochem Biophys 503:24852 Zhu X, Gallogly MM, Mieyal JJ, Anderson VE, Sayre LM (2009) Covalent cross-linking of glutathione and carnosine to proteins by 4-oxo-2-nonenal

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Previously, the peptides in question were severely restricted because of safety concerns, and pharmaceutical-grade forms were available only via limited channels

In ALS patients, it has been found that A co-localized with oxidative damage markers such as heme oxygenase-1, and nitro-tyrosine in abnormal neurons and an increased cleaved caspase-3 immunoreactivity in motor neurons (Calingasan et al., 2005)

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