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In the SURPASS clinical trial program, which enrolled over 6,000 participants with type 2 diabetes, the most common side effects included nausea (reported in 12% to 29% of patients), diarrhea (13% to 16%), vomiting (5% to 10%), constipation (6% to 7%), and abdominal discomfort

They are optimal for their insulinotropic effect exclusively when glucose levels are elevated, thereby providing the capacity to decrease plasma glucose while mitigating the risk of hypoglycemia

This is consistent with the known role of ARF6 as a negative regulator of ferroptosis in cancers such as pancreatic and gastric carcinoma (Geng and Wu, 2022)

GLP-1 receptor agonists work by mimicking the glucagon-like peptide-1 hormone naturally produced in the gut after eating

Doi:10.1046/j.1523-1747.1999.00708.x Ionescu M, Frohman LA

This dose can be increased by 2.5 mg every four weeks for additional diabetes control or to achieve weight loss goals up to a maximum dose of 15 mg once a week