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A study published in Neurology by Stanley et al

The outcome suggested that a transient and limited increase in gut permeability compared with the unregulated breach of the gut barrier function due to the TJ deregulation and epithelial cell apoptosis can rather lead to a dominant regulatory immune response to gut microbiota antigens and to a net anti-inflammatory effect

3.Vukojevic J, et al

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For neuroprotection protocols, standard dosing uses 0.25 to 0.5 mg daily via subcutaneous or oral administration