doi:10.1111/j.1365-2362.1980.tb00026.x 154
The HFI series of compounds, e.g., 37 (HFI 419) identified in 2008 after the virtual screening are much more drug-like than the hexapeptides 11 (AL-11), 12 (IVDE77), and the potent macrocyclic Ang IV analogue 23 (HA08) and can hopefully after further systematic optimization be converted into bioactive small molecules with capacity to cross the blood-brain barrier
A3: Yes, but a professional consultation is necessary to ensure suitability and customize the dosage
However, some disadvantages include: (a) rapid degradation by serum or tissue peptidases
For these measurements, EC1 was used (ESM Table 2)
If the urge feels more like a psychological pull than a physical stomach sensation, the medication may be working while behavioral patterns remain