Low dose GLP-1 therapy attenuates pathological cardiac and hepatic remodelling in HFpEF independent of weight loss
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Oral GLP-1 RAs have been introduced to improve convenience, although their weight-loss efficacy is generally lower and gastrointestinal adverse effects tend to be more pronounced than with injectable formulations [39, 40]
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Total calorie intake should not drop too fast
The pathophysiology involves mechanical insufficiency of the lymphatic system, leading to fluid stasis, chronic inflammation, adipose tissue deposition, and progressive fibrosis