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Figure 4 Ex(9-39) (600 nmol/kg, ip) was administered with a single shot at 75 min prior to ipGTT to assess the involvement of GLP-1R signaling, followed by administration of ISF or control solution at 60 min before ipGTT ( Figure 4I )

Cardiovascular outcome trials have established benefits for specific agents: the LEADER trial for liraglutide, SUSTAIN-6 for injectable semaglutide, and REWIND for dulaglutide demonstrated reduced risk of major adverse cardiovascular events in patients with type 2 diabetes

Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent- mediated central mechanisms

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Early studies suggest it may reinforce antioxidant defenses and even support neurological health [17]