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Melatonin has been used in clinical trials to increase embryo quality in women undergoing IVF, and it has been used in several studies with women with PCOS to normalize hormones and increase egg quality.[ref][ref][ref][ref] Melatonin also may play a role in keeping the mothers body from rejecting the fetus.[ref] Related Article: Genetic links to infertility for women Gut Microbiome: It makes sense that melatonin would affect gut microbes since it is both an antioxidant and an immune modulator