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GLP-1 receptor agonists like semaglutide and tirzepatide appear to act on the same brain circuits that drive both overeating and alcohol consumption

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[email protected] OPEN ACCESS PUBLISHED: 30 April 2026 CITATION Joshi, A., and Li, D., 2026

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As liraglutide alone did not improve cardiorespiratory fitness compared with placebo, we speculate that the improvements observed with combined exercise and liraglutide were mainly due to exercise-induced physiological adaptations [51], rather than weight loss per se

PMID 22300961