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However, another study on mice with LRP5/LRP6 gene knockout suggests that the inhibitory effect on LR in the absence of these co-receptors lasts for up to 72 h, significantly reducing the rapid proliferative phase of hepatocyte regeneration (Yang et al., 2014)

Importantly, the review also notes that individual responses to incretin-based therapies can vary substantially, and weight regain commonly occurs if treatment is discontinued, highlighting the chronic nature of obesity management

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ROS dysregulation in metabolic diseases ROS play a pivotal role in the etiology of metabolic diseases such as diabetes and obesity [25]

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