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Mol Metab 2025;95:102118
Clinical trials involving approximately 900 participants across six studies demonstrated excellent safety and tolerability
Preclinical studies show reductions in caloric intake and fat accumulation, suggesting its role in experimental research on metabolic regulation, obesity, and neuroendocrine energy homeostasis
No non-diabetic participants on GLP-1 RAs were enrolled, limiting the generalizability of findings to this subgroup
Nausea, vomiting, dyspepsia, or abdominal distension in those taking GLP-1 agonists predict increased residual gastric contents
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