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Cardiovascular outcome trials of tirzepatideSURPASS-CVOT and SUMMIThave shown encouraging signals, with SURPASS-CVOT meeting the prespecified criteria for non-inferiority for MACEs and a 16% reduction in all-cause mortality [86]

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When combined with exercise and a healthy diet, they help with weight loss and provide benefits including increased energy, mood enhancement, and gradual weight loss

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Retatrutide appeared to induce lean mass loss in similar proportions to GLP-1RAs alone, whereas PTT-A has shown robust fat reduction without significant decrease in muscle mass, highlighting the potential of selective multi-agonists to preserve skeletal muscle during weight loss [66, 67]