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In conclusion, the BP lowering effect of DPP-4i may be reduced by stimulating sympathetic activity via reducing degradation of GLP-1 and substance P when combined with ACEI, especially in high-dose ACEI

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doi: 10.1158/0008-5472.CAN-12-2217 65 RackBSchindlbeckCJckstockJAndergassenUHeppPZwingersTet al