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Preclinical studies have used a range of concentrations, including: In vivo murine models: 510 mg/kg (micrograms per kilogram body weight) In vitro cellular assays: 120 M (micromolar concentrations) Note: These concentrations are from FOXO4-DRI preclinical studies only and should not be extrapolated to human or animal use

The co-administration of SERT with SILY showed marked mitigation of these changes, suggesting that SILY was not only beneficial when administered alone, but it also possibly accentuated the effects of SERT

Glutamate is the most abundant excitatory transmitter in the central nervous system, utilized at 50- 70% of cortical synapses (1, 2)

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