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Receptor activation stimulates intracellular cAMP production and downstream PKA-dependent signaling, driving glucose-stimulated insulin secretion, glucagon suppression, and gastric motility regulation
The goal is not just temporary appetite suppression
By mimicking the effects of GLP-1, semaglutide can help lower blood sugar levels in people with certain conditions
Nat Rev Endocrinol 19(11):639654 Bai L et al (2019) Genetic identification of vagal sensory neurons that control feeding
2 The design of the study and key baseline characteristics of SUSTAIN-6 are described in Box 1
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