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Antagonists MIA-602 and MIA-690 were among the most potent anti-tumor analogs and also displayed anti-inflammatory activities 47 powerfully hindering tumor growth

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When activated, these receptors trigger signaling cascades that dampen pro-inflammatory cytokine production, particularly interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-)

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Independently confirmed in 4 people (0.2%) on semaglutide 2.4 mg and 1 person (under 0.1%) on placebo in the pooled programme