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While phase 2 and phase 3 trials provide substantial data, they involve hundreds to thousands of participants over months

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They noted that 16 compound has a strong effect on MCF-7 cell toxicity with IC 50 of ~ 9.7 M via inducing ER degradation [63]

Some possible explanations for the contradictory finding include the small sample sizes of the studies, the lack of multicenter or large-sample size studies to verify the reproducibility and generalizability of the results, and the effect of discontinuation conditions and depression itself on the validation of the conclusions of the Chengdu-based study (Figure 1)

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